It is also absorbed via inhalation, and to a lesser degree, through the skin. Dr. Ed Kaplan answered. In chronic misuse, most of the volatile substances produce memory impairment, loss of smell, and neurological changes. toluene side effects. The effects of chronic exposure to toluene were attending a toxic vapor rehabilitation program. A total of 20 male rabbits were used as control and experimental groups. A … PMCID: PMC1035211. It is also used in paints, lacquers, inks, adhesives, rubber, and cleaning agents. Experiment I was designed to assess the effects of chronic toluene exposure on sleep. Toluene is responsible not only for instant inebriation but also for devastating neurotoxicity and death in the chronic abusers. and mounted in a ste-reotaxic frame (David Kopff Instruments, Munich). Potential Health Effects . Neurobehavioural tests were undertaken by 30 female workers exposed to toluene and matched controls with low occupational exposure to toluene. Reference Dose for Chronic Oral Exposure (RfD) Substance Name — Toluene CASRN — 108-88-3 Section I.A. I. It is used to manufacture benzene, urethane raw materials, and other organic chemicals. The main effect of toluene is on the brain and nervous system, but animals exposed to moderate or high levels of toluene also show harmful effects in their liver, kidneys, and lungs and impaired immune function. No effects of toluene exposure were found on absolute and relative weight of kidney, liver or brain. The severity of nephropathy was slightly increased in exposed female rats. Chronic Health Hazard Assessments for Noncarcinogenic Effects . To address this, we investigated effects of adolescent chronic intermittent toluene (CIT) inhalation on gene expression and DNA methylation profiles within the rat medial prefrontal cortex (mPFC), which undergoes maturation throughout adolescence and has been implicated in toluene‐induced cognitive deficits. for 4 h (09:00-11:00, 13:00-15:00)] every day for 3 weeks on immunoreactivity for tyrosine hydroxylase (TH), the rate limiting enzyme of catecholamine synthesis, in the rat forebrain were studied. It is used in the production of pharmaceuticals, dyes, and Abstract. Focal degenerative liver changes were observed in both sexes of both species. The toluene in blood concentrations for the exposed … Toluene is sometimes used as a recreational inhalant ("glue sniffing"), likely on account of its euphoric and dissociative effects. 38 years experience Hematology and Oncology. Chronic Exposure. 90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Le toluène, également appelé méthylbenzène ou phénylméthane est un hydrocarbure aromatique sous la forme d'un liquide transparent, très répandu et utilisé comme produit de départ industriel ou comme solvant.Sa manipulation comporte des risques pour la santé de l’utilisateur. Animal studies do not indicate that toluene exposure results in reproductive effects. Symptoms arise due to severe hypokalemia and metabolic acidosis, most prominent being weakness and paralysis, as well as neurological deficits and gastrointestinal irritation. No long-term effects due to acute toluene exposure have been reported. 1990 July; 47(7): 480–484. Inhaled toluene is rapidly absorbed by the lungs, from where it easily enters the highly vascularized lipid-rich brain. The effects of acute and chronic toluene exposure on the hypnotic effect, the righting reflex latencies and the blood and tissue toluene contents were studied in rats during development. 8 Myriad accounts of cases of acute and chronic toluene-induced encephalopathy exist and occur in the setting of accidental or intentional inhalation. In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. To address this, we investigated effects of adolescent chronic intermittent toluene (CIT) inhalation on gene expression and DNA methylation profiles within the rat medial prefrontal cortex (mPFC), which undergoes maturation throughout adolescence and has been implicated in toluene-induced cognitive deficits. Chronic misusers usually have decreased sensory capacities due to neurological damage. 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