The first exam, the USMLE Step 1, is one of the hardest. The sheer volume of knowledge you have to assimilate is the most difficult part of medical school and the fact that every community general practitioner has it down and treats it as common knowledge really blew my mind. I was born the year before start of Chinese Culture Revolution, in a middle sized city one hour train ride away from Tsingtao (Tsingtao Beer is made there). About 2/3 of the class took biochem in undergrad, and the third that did not is struggling (as far as I can tell). The first two years of med school are almost like a continuation of college. But it is not what you think! Each course and rotation presents its own unique challenges, but some are notoriously more difficult. Q. You'll just have to wait and see how well you do. Medical school, and by a wide margin, at least for me. A. Medical school is a whole 'nother ball game. I would like to take similar (of course more basic) courses in undergrad that correlate so when I go to med school I'll have had a "primer" course and not trying to grasp the overall concepts as much but can rather focus on it being a more in depth and detailed review of what I had somewhat already covered. The board exams to become a certified medical doctor are universally regarded as one of the most difficult parts of medical school. Much of the info you learn in ochem is not even used in med school. Pathology, a year-long course in the sophomore year, is hands-down the most difficult for me, followed by Microbiology. In college, you are expected to have clinical experience, volunteer experience, research experience, some qualities that make you unique and memorable, all while scoring a perfect GPA and top MCAT score. Classes. A medical school is a tertiary educational institution, or part of such an institution, that teaches medicine, and awards a professional degree for physicians and surgeons. Anybody who thinks that getting into medical school is the hardest part probably has not had to deal with the day to day grind that is medical school. For instance, we have Gross Anatomy, Physiology, and Biochem as monster classes in a traditional curriculum; but those who have systems-based curricula will instead have blocks dedicated to specific systems with the subjects sprinkled into each of them. What's the hardest subject in medical school? I'm trying to figure out what the hardest subjects are in medical school. Medical schools, which are already hard to get into, are getting harder each year. In medical school and residency, you have less time, so the thought of performing multiple extracurriculars isn’t even considered. You go to class, study, and sit for exams. 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